View source for 6a3k


==Crystal structure of cytochrome c' from Shewanella benthica DB6705==
<StructureSection load='6a3k' size='340' side='right'caption='[[6a3k]], [[Resolution|resolution]] 1.71&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6a3k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Shewanella_sp._DB6705 Shewanella sp. DB6705]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6A3K FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.71&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6a3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a3k OCA], [https://pdbe.org/6a3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6a3k RCSB], [https://www.ebi.ac.uk/pdbsum/6a3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6a3k ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A2Z6I6U9_SHESP A0A2Z6I6U9_SHESP] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The stability of dimeric cytochrome c' from a thermophile, as compared with that of a homologous mesophilic counterpart, is attributed to strengthened interactions around the heme and at the subunit-subunit interface, both of which are molecular interior regions. Here, we showed that interactions in the equivalent interior regions of homologous cytochromes c' from two psychrophiles, Shewanella benthica and Shewanella violacea (SBCP and SVCP, respectively) were similarly weakened as compared with those of the counterparts of psychrophilic Shewanella livingstonensis and mesophilic Shewanella amazonensis (SLCP and SACP, respectively), and consistently the stability of SVCP, SLCP, and SACP increased in that order. Therefore, the stability of cytochromes c' from the psychrophile, mesophile, and thermophile is systematically regulated in their molecular interior regions. Unexpectedly, however, the stability of SBCP was significantly higher than that of SVCP, and the former had additional molecular surface interactions. Collectively, SBCP had weakened interior interactions like SVCP did, but the former was stabilized at the molecular surface as compared with the latter, implying complex multiple adaptation of the proteins because the psychrophilic sources of SBCP and SVCP are also piezophilic, thriving in deep-sea extreme environments of low temperature and high hydrostatic pressure.

Stability of cytochromes c' from psychrophilic and piezophilic Shewanella species: implications for complex multiple adaptation to low temperature and high hydrostatic pressure.,Suka A, Oki H, Kato Y, Kawahara K, Ohkubo T, Maruno T, Kobayashi Y, Fujii S, Wakai S, Lisdiana L, Sambongi Y Extremophiles. 2019 Mar;23(2):239-248. doi: 10.1007/s00792-019-01077-9. Epub 2019, Jan 28. PMID:30689055<ref>PMID:30689055</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6a3k" style="background-color:#fffaf0;"></div>

==See Also==
*[[Cytochrome C 3D structures|Cytochrome C 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Shewanella sp. DB6705]]
[[Category: Fujii S]]
[[Category: Kato Y]]
[[Category: Kawahara K]]
[[Category: Kobayashi Y]]
[[Category: Maruno T]]
[[Category: Ohkubo T]]
[[Category: Oki H]]
[[Category: Sambongi Y]]
[[Category: Suka A]]
[[Category: Wakai S]]