View source for 6a90


==Complex of voltage-gated sodium channel NavPaS from American cockroach Periplaneta americana and Dc1a==
<SX load='6a90' size='340' side='right' viewer='molstar' caption='[[6a90]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6a90]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Diguetia_canities Diguetia canities] and [https://en.wikipedia.org/wiki/Periplaneta_americana Periplaneta americana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A90 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6A90 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6a90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a90 OCA], [https://pdbe.org/6a90 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6a90 RCSB], [https://www.ebi.ac.uk/pdbsum/6a90 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6a90 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SCNA1_PERAM SCNA1_PERAM] Mediates the voltage-dependent sodium ion permeability of excitable membranes.[RuleBase:RU361132]<ref>PMID:28183995</ref> 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Animal toxins that modulate the activity of Nav channels are broadly divided into two categories-pore blockers and gating modifiers. The pore blockers tetrodotoxin (TTX) and saxitoxin (STX) are responsible for pufferfish and shellfish poisoning in humans, respectively. Here we present structures of the insect Nav channel NavPaS bound to a gating modifier toxin Dc1a at 2.8 A and in the presence of TTX or STX at 2.6 A and 3.2 A resolution, respectively. Dc1a inserts into the cleft between VSDII and the pore of NavPaS, making key contacts with both domains. The structures with bound TTX or STX reveal the molecular details for the specific blockade of Na(+) access to the selectivity filter from the extracellular side by these guanidinium toxins. The structures shed light on structure-based development of Nav channel drugs.

Structural basis for the modulation of voltage-gated sodium channels by animal toxins.,Shen H, Li Z, Jiang Y, Pan X, Wu J, Cristofori-Armstrong B, Smith JJ, Chin YKY, Lei J, Zhou Q, King GF, Yan N Science. 2018 Jul 26. pii: science.aau2596. doi: 10.1126/science.aau2596. PMID:30049784<ref>PMID:30049784</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6a90" style="background-color:#fffaf0;"></div>

==See Also==
*[[Ion channels 3D structures|Ion channels 3D structures]]
== References ==
<references/>
__TOC__
</SX>
[[Category: Diguetia canities]]
[[Category: Large Structures]]
[[Category: Periplaneta americana]]
[[Category: Chin YKY]]
[[Category: Cristofori-Armstrong B]]
[[Category: Jiang Y]]
[[Category: King GF]]
[[Category: Lei JL]]
[[Category: Pan XJ]]
[[Category: Shen HZ]]
[[Category: Smith JJ]]
[[Category: Wu JP]]
[[Category: Yan N]]
[[Category: Zhou Q]]
[[Category: Li ZQ]]