View source for 6agi


==Crystal Structure of EFHA2 in Ca-binding State==
<StructureSection load='6agi' size='340' side='right'caption='[[6agi]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6agi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AGI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AGI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.799&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6agi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6agi OCA], [https://pdbe.org/6agi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6agi RCSB], [https://www.ebi.ac.uk/pdbsum/6agi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6agi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MICU3_HUMAN MICU3_HUMAN] May play a role in mitochondrial calcium uptake.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The mitochondrial Ca(2+) uniporter complex (MCUC) is responsible for Ca(2+) influx into the mitochondrial matrix, playing critical roles in various mitochondrial functions. Eukaryotic MCUC consists of multiple subunits, and its Ca(2+) influx activity is controlled by regulatory subunits, including mitochondrial Ca(2+) uptake 1 (MICU1) and its paralogs (MICU2 and MICU3). However, the underlying mechanism remains unclear. Here, we determined multiple crystal structures of MICU2 and MICU3 from Homo sapiens. Our data demonstrate that distinct MICU protein N-domains determine the specific type of MICU dimers that perform the opposing roles in mitochondrial Ca(2+) uptake at low cytosolic Ca(2+) levels. In contrast, at high cytosolic Ca(2+) levels, all MICU proteins undergo dimer rearrangement induced by Ca(2+) binding, which releases the suppression of the MCUC pore-forming subunit and promotes the influx of large amounts of Ca(2+). Altogether, our results elucidate the delicate mechanism of mitochondrial Ca(2+) uptake regulation by MICU proteins.

Dimerization of MICU Proteins Controls Ca(2+) Influx through the Mitochondrial Ca(2+) Uniporter.,Xing Y, Wang M, Wang J, Nie Z, Wu G, Yang X, Shen Y Cell Rep. 2019 Jan 29;26(5):1203-1212.e4. doi: 10.1016/j.celrep.2019.01.022. PMID:30699349<ref>PMID:30699349</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6agi" style="background-color:#fffaf0;"></div>

==See Also==
*[[Calcium uptake protein 3D structures|Calcium uptake protein 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Xue Y]]
[[Category: Yangfei X]]
[[Category: Yuequan S]]