View source for 6ajm


==Crystal structure of apo AtaTR==
<StructureSection load='6ajm' size='340' side='right'caption='[[6ajm]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6ajm]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AJM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AJM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.604&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ajm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ajm OCA], [https://pdbe.org/6ajm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ajm RCSB], [https://www.ebi.ac.uk/pdbsum/6ajm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ajm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/J7QA90_ECOLX J7QA90_ECOLX] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
AtaT-AtaR is an enterohemorrhagic Escherichia coli toxin-antitoxin system that modulates cellular growth under stress conditions. AtaT and AtaR act as a toxin and its repressor, respectively. AtaT is a member of the GNAT family, and the dimeric AtaT acetylates the alpha-amino group of the aminoacyl moiety of methionyl initiator tRNA(fMet), thereby inhibiting translation initiation. The crystallographic analysis of the AtaT-AtaR complex revealed that the AtaT-AtaR proteins form a heterohexameric [AtaT-(AtaR4)-AtaT] complex, where two V-shaped AtaR dimers bridge two AtaT molecules. The N-terminal region of AtaR is required for its dimerization, and the C-terminal region of AtaR interacts with AtaT. The two AtaT molecules are spatially separated in the AtaT-AtaR complex. AtaT alone forms a dimer in solution, which is enzymatically active. The present structure, in which AtaR prevents AtaT from forming an active dimer, reveals the molecular basis of the AtaT toxicity repression by the antitoxin AtaR.

Crystal Structure of the Enterohemorrhagic Escherichia coli AtaT-AtaR Toxin-Antitoxin Complex.,Yashiro Y, Yamashita S, Tomita K Structure. 2018 Nov 21. pii: S0969-2126(18)30424-6. doi:, 10.1016/j.str.2018.11.005. PMID:30612860<ref>PMID:30612860</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6ajm" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Tomita K]]
[[Category: Yamashita S]]
[[Category: Yashiro Y]]