View source for 6anm


==Structure of D-Leu-D-Phe-2-Abz-D-Ala at 0.64 Angstrom==
<StructureSection load='6anm' size='340' side='right'caption='[[6anm]], [[Resolution|resolution]] 0.64&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6anm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ANM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ANM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.64&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BE2:2-AMINOBENZOIC+ACID'>BE2</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DLE:D-LEUCINE'>DLE</scene>, <scene name='pdbligand=DPN:D-PHENYLALANINE'>DPN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6anm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6anm OCA], [https://pdbe.org/6anm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6anm RCSB], [https://www.ebi.ac.uk/pdbsum/6anm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6anm ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Herein we report the unique conformations adopted by linear and cyclic tetrapeptides (CTPs) containing 2-aminobenzoic acid (2-Abz) in solution and as single crystals. The crystal structure of the linear tetrapeptide H2N-D-Leu-D-Phe-2-Abz-D-Ala-COOH (1) reveals a novel planar peptidomimetic beta-turn stabilized by three hydrogen bonds and is in agreement with its NMR structure in solution. While CTPs are often synthetically inaccessible or cyclize in poor yield, both 1 and its N-Me-D-Phe analogue (2) adopt pseudo-cyclic frameworks enabling near quantitative conversion to the corresponding CTPs 3 and 4. The crystal structure of the N-methylated peptide (4) is the first reported for a 2-Abz containing CTP and reveals a distinctly planar 13-membered ring which is also evident in solution. The N-methylation of D-Phe results in a peptide bond inversion compared to the solution conformation of 3.

Crystal and NMR Structures of a Peptidomimetic beta-turn which provides facile synthesis of 13-membered Cyclic Tetrapeptides.,Cameron AJ, Squire CJ, Edwards PJB, Harjes E, Sarojini V Chem Asian J. 2017 Nov 2. doi: 10.1002/asia.201701422. PMID:29098772<ref>PMID:29098772</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6anm" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Cameron AJ]]
[[Category: Sarojini V]]
[[Category: Squire CJ]]