View source for 6avq


==The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha-V beta-3 Integrin via Steric Hindrance==
<SX load='6avq' size='340' side='right' viewer='molstar' caption='[[6avq]], [[Resolution|resolution]] 35.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6avq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AVQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AVQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 35&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6avq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6avq OCA], [https://pdbe.org/6avq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6avq RCSB], [https://www.ebi.ac.uk/pdbsum/6avq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6avq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ITAV_HUMAN ITAV_HUMAN] The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

==See Also==
*[[Antibody 3D structures|Antibody 3D structures]]
*[[Integrin 3D structures|Integrin 3D structures]]
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</SX>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Backovic M]]
[[Category: Borst AJ]]
[[Category: DiMaio F]]
[[Category: Ginsberg M]]
[[Category: James ZN]]
[[Category: Rey FA]]
[[Category: Veesler D]]
[[Category: Zagotta WN]]