View source for 6aye


==Human apo-TRPML3 channel at pH 7.4==
<SX load='6aye' size='340' side='right' viewer='molstar' caption='[[6aye]], [[Resolution|resolution]] 4.06&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6aye]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AYE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AYE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.06&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6aye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aye OCA], [https://pdbe.org/6aye PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6aye RCSB], [https://www.ebi.ac.uk/pdbsum/6aye PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6aye ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MCLN3_HUMAN MCLN3_HUMAN] Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:18369318, PubMed:19497048, PubMed:19522758, PubMed:19885840). Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway (PubMed:21245134). Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle growth (By similarity). Involved in the regulation of autophagy (PubMed:19522758). Through association with GABARAPL2 may be involved in autophagosome formation possibly providing Ca(2+) for the fusion process (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840). Possible heteromeric ion channel assemblies with TRPV5 show pharmacological similarity with TRPML3 (PubMed:23469151).[UniProtKB:Q8R4F0]<ref>PMID:18369318</ref> <ref>PMID:19497048</ref> <ref>PMID:19522758</ref> <ref>PMID:19885840</ref> <ref>PMID:21245134</ref> <ref>PMID:23469151</ref> 
== References ==
<references/>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Jia Q]]
[[Category: Li H]]
[[Category: Li M]]
[[Category: Li X]]
[[Category: Su D]]
[[Category: Yang J]]
[[Category: Zhou X]]