View source for 6bf6


==Cryo-EM structure of human insulin degrading enzyme==
<SX load='6bf6' size='340' side='right' viewer='molstar' caption='[[6bf6]], [[Resolution|resolution]] 6.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6bf6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BF6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BF6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bf6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bf6 OCA], [https://pdbe.org/6bf6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bf6 RCSB], [https://www.ebi.ac.uk/pdbsum/6bf6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bf6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> 

==See Also==
*[[Insulin-degrading enzyme 3D structures|Insulin-degrading enzyme 3D structures]]
== References ==
<references/>
__TOC__
</SX>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bailey LJ]]
[[Category: Carragher B]]
[[Category: Kossiakoff AA]]
[[Category: Liang WG]]
[[Category: Potter SC]]
[[Category: Tan YZ]]
[[Category: Tang WJ]]
[[Category: Wei H]]
[[Category: Zhang Z]]