View source for 6bgi


==Cryo-EM structure of the TMEM16A calcium-activated chloride channel in nanodisc==
<SX load='6bgi' size='340' side='right' viewer='molstar' caption='[[6bgi]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6bgi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BGI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BGI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bgi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bgi OCA], [https://pdbe.org/6bgi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bgi RCSB], [https://www.ebi.ac.uk/pdbsum/6bgi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bgi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ANO1_MOUSE ANO1_MOUSE] Calcium-activated chloride channel (CaCC) which plays an important role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.<ref>PMID:18585372</ref> <ref>PMID:18724360</ref> <ref>PMID:21908539</ref> <ref>PMID:22002868</ref> <ref>PMID:22075693</ref> 
== References ==
<references/>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Bulkley D]]
[[Category: Chen T]]
[[Category: Cheng Y]]
[[Category: Craik CS]]
[[Category: Dang S]]
[[Category: Feng S]]
[[Category: Jan LY]]
[[Category: Jan YN]]
[[Category: Lolicato M]]
[[Category: Minor Jr DL]]
[[Category: Peters CJ]]
[[Category: Qi J]]
[[Category: Tien J]]
[[Category: Ye W]]
[[Category: Zhao J]]
[[Category: Zuberbuhler K]]