View source for 6bgj


==Cryo-EM structure of the TMEM16A calcium-activated chloride channel in LMNG==
<SX load='6bgj' size='340' side='right' viewer='molstar' caption='[[6bgj]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6bgj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BGJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BGJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bgj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bgj OCA], [https://pdbe.org/6bgj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bgj RCSB], [https://www.ebi.ac.uk/pdbsum/6bgj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bgj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ANO1_MOUSE ANO1_MOUSE] Calcium-activated chloride channel (CaCC) which plays an important role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.<ref>PMID:18585372</ref> <ref>PMID:18724360</ref> <ref>PMID:21908539</ref> <ref>PMID:22002868</ref> <ref>PMID:22075693</ref> 
== References ==
<references/>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Bulkley D]]
[[Category: Chen T]]
[[Category: Cheng Y]]
[[Category: Craik CS]]
[[Category: Dang S]]
[[Category: Feng S]]
[[Category: Jan LY]]
[[Category: Jan YN]]
[[Category: Lolicato M]]
[[Category: Minor Jr DL]]
[[Category: Peters CJ]]
[[Category: Qi L]]
[[Category: Tien J]]
[[Category: Ye W]]
[[Category: Zhao J]]
[[Category: Zuberbuhler K]]