View source for 6bnm


==Crystal Structure of the P-Rex2 PH domain==
<StructureSection load='6bnm' size='340' side='right'caption='[[6bnm]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6bnm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BNM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BNM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bnm OCA], [https://pdbe.org/6bnm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bnm RCSB], [https://www.ebi.ac.uk/pdbsum/6bnm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bnm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PREX2_HUMAN PREX2_HUMAN] Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase.<ref>PMID:15304342</ref> <ref>PMID:15304343</ref> <ref>PMID:15897194</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cash JN]]
[[Category: Sharma PV]]
[[Category: Tesmer JJG]]