View source for 6bq1


==Human PI4KIIIa lipid kinase complex==
<SX load='6bq1' size='340' side='right' viewer='molstar' caption='[[6bq1]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6bq1]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BQ1 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E4S:5-{2-amino-1-[4-(morpholin-4-yl)phenyl]-1H-benzimidazol-6-yl}-N-(2-fluorophenyl)-2-methoxypyridine-3-sulfonamide'>E4S</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bq1 OCA], [https://pdbe.org/6bq1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bq1 RCSB], [https://www.ebi.ac.uk/pdbsum/6bq1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bq1 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/PI4KA_HUMAN PI4KA_HUMAN] Bilateral perisylvian polymicrogyria;Autosomal recessive spastic paraplegia type 84;Combined immunodeficiency-enteropathy spectrum. The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/PI4KA_HUMAN PI4KA_HUMAN] Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate.<ref>PMID:10101268</ref> <ref>PMID:23229899</ref> 

==See Also==
*[[Phosphatidylinositol 4-kinase|Phosphatidylinositol 4-kinase]]
== References ==
<references/>
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</SX>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Baskin J]]
[[Category: Camilli PD]]
[[Category: Dobbs K]]
[[Category: Lees JA]]
[[Category: Notarangelo LD]]
[[Category: Oh M]]
[[Category: Reinisch KM]]
[[Category: Schauder CM]]
[[Category: Walz T]]
[[Category: Yu X]]
[[Category: Zhang Y]]