View source for 6buz


==Cryo-EM structure of CENP-A nucleosome in complex with kinetochore protein CENP-N==
<SX load='6buz' size='340' side='right' viewer='molstar' caption='[[6buz]], [[Resolution|resolution]] 3.92&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6buz]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BUZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BUZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.92&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6buz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6buz OCA], [https://pdbe.org/6buz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6buz RCSB], [https://www.ebi.ac.uk/pdbsum/6buz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6buz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CENPA_HUMAN CENPA_HUMAN] Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).<ref>PMID:20739937</ref> <ref>PMID:21478274</ref> 

==See Also==
*[[Centromere protein 3D structure|Centromere protein 3D structure]]
*[[Trypanothione reductase|Trypanothione reductase]]
== References ==
<references/>
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[[Category: Escherichia coli]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Bai Y]]
[[Category: Chittori S]]
[[Category: Hong J]]
[[Category: Kelly AE]]
[[Category: Subramaniam S]]