View source for 6bwf


==4.1 angstrom Mg2+-unbound structure of mouse TRPM7==
<SX load='6bwf' size='340' side='right' viewer='molstar' caption='[[6bwf]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6bwf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BWF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BWF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bwf OCA], [https://pdbe.org/6bwf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bwf RCSB], [https://www.ebi.ac.uk/pdbsum/6bwf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bwf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TRPM7_MOUSE TRPM7_MOUSE] Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).<ref>PMID:11385574</ref> 
== References ==
<references/>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Abiria SA]]
[[Category: Clapham DE]]
[[Category: Duan J]]
[[Category: Li Z]]
[[Category: Zhang J]]