View source for 6bwj


==Crystal structure of the TRPV2 ion channel in complex with RTx==
<StructureSection load='6bwj' size='340' side='right'caption='[[6bwj]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6bwj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BWJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BWJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6EU:RESINIFERATOXIN'>6EU</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bwj OCA], [https://pdbe.org/6bwj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bwj RCSB], [https://www.ebi.ac.uk/pdbsum/6bwj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bwj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/G1SNM3_RABIT G1SNM3_RABIT] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Transient receptor potential vanilloid (TRPV) channels are activated by ligands and heat and are involved in various physiological processes. In contrast to the architecturally related voltage-gated cation channels, TRPV1 and TRPV2 subtypes possess another activation gate at the selectivity filter that can open widely enough to permeate large organic cations. Despite recent structural advances, the mechanism of selectivity filter gating and permeation for both metal ions and large molecules by TRPV1 or TRPV2 is not well known. Here, we determined two crystal structures of rabbit TRPV2 in its Ca(2+)-bound and resiniferatoxin (RTx)- and Ca(2+)-bound forms, to 3.9 A and 3.1 A, respectively. Notably, our structures show that RTx binding leads to two-fold symmetric opening of the selectivity filter of TRPV2 that is wide enough for large organic cation permeation. Combined with functional characterizations, our studies reveal a structural basis for permeation of Ca(2+) and large organic cations in TRPV2.

Conformational plasticity in the selectivity filter of the TRPV2 ion channel.,Zubcevic L, Le S, Yang H, Lee SY Nat Struct Mol Biol. 2018 May;25(5):405-415. doi: 10.1038/s41594-018-0059-z. Epub, 2018 Apr 30. PMID:29728656<ref>PMID:29728656</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6bwj" style="background-color:#fffaf0;"></div>

==See Also==
*[[Ion channels 3D structures|Ion channels 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Le S]]
[[Category: Lee SY]]
[[Category: Yang H]]
[[Category: Zubcevic L]]