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==LyeTxI-b, a synthetic peptide derived from Lycosa erythrognatha spider venom, shows potent antibiotic activity, in vitro and in vivo==
<StructureSection load='6cl3' size='340' side='right'caption='[[6cl3]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6cl3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lycosa_erythrognatha Lycosa erythrognatha]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CL3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CL3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cl3 OCA], [https://pdbe.org/6cl3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cl3 RCSB], [https://www.ebi.ac.uk/pdbsum/6cl3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cl3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LYT1_LYCER LYT1_LYCER] 
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== Publication Abstract from PubMed ==
The antimicrobial peptide LyeTxI isolated from the venom of the spider Lycosa erythrognatha is a potential model to develop new antibiotics against bacteria and fungi. In this work, we studied a peptide derived from LyeTxI, named LyeTxI-b, and characterized its structural profile and its in vitro and in vivo antimicrobial activities. Compared to LyeTxI, LyeTxI-b has an acetylated N-terminal and a deletion of a His residue, as structural modifications. The secondary structure of LyeTxI-b is a well-defined helical segment, from the second amino acid to the amidated C-terminal, with no clear partition between hydrophobic and hydrophilic faces. Moreover, LyeTxI-b shows a potent antimicrobial activity against Gram-positive and Gram-negative planktonic bacteria, being 10-fold more active than the native peptide against Escherichia coli. LyeTxI-b was also active in an in vivo model of septic arthritis, reducing the number of bacteria load, the migration of immune cells, the level of IL-1beta cytokine and CXCL1 chemokine, as well as preventing cartilage damage. Our results show that LyeTxI-b is a potential therapeutic model for the development of new antibiotics against Gram-positive and Gram-negative bacteria.

LyeTxI-b, a Synthetic Peptide Derived From Lycosa erythrognatha Spider Venom, Shows Potent Antibiotic Activity in Vitro and in Vivo.,Reis PVM, Boff D, Verly RM, Melo-Braga MN, Cortes ME, Santos DM, Pimenta AMC, Amaral FA, Resende JM, de Lima ME Front Microbiol. 2018 Apr 6;9:667. doi: 10.3389/fmicb.2018.00667. eCollection, 2018. PMID:29681894<ref>PMID:29681894</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6cl3" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Lycosa erythrognatha]]
[[Category: Resende JM]]
[[Category: Verly RM]]
[[Category: De Lima ME]]
[[Category: Dos Reis PV]]