View source for 6cmv


==Crystal structure of Archaeal Biofilm Regulator (AbfR2) from Sulfolobus acidocaldarius==
<StructureSection load='6cmv' size='340' side='right'caption='[[6cmv]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6cmv]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CMV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6CMV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6cmv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cmv OCA], [http://pdbe.org/6cmv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cmv RCSB], [http://www.ebi.ac.uk/pdbsum/6cmv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cmv ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The small winged helix-turn-helix (wHTH) proteins of the Lrs14 family are major transcriptional regulators and act as archaeal biofilm regulators (AbfRs) in the crenarchaeote Sulfolobus acidocaldarius. Here, the first crystal structure of an AbfR ortholog, AbfR2, the deletion of which is known to impair biofilm formation, is presented. Like most other wHTH orthologs, AbfR2 is dimeric in solution as well as in its 2.45 A resolution crystal structure. Given the presence of three independent AbfR2 dimers in the asymmetric unit, the crystal structure shows a considerable degree of conformational variation within the dimer, the antiparallel orientations of which are stabilized by coiled-coil interaction between H4 helices. Conserved anchor interactions between helices H0 and H4 of AbfR2 further contribute to dimer stabilization. The combined structural and bioinformatic analysis reveals cluster-specific structural differences between different members of the Lrs14 protein family.

Crystal structure of an Lrs14-like archaeal biofilm regulator from Sulfolobus acidocaldarius.,Vogt MS, Volpel SL, Albers SV, Essen LO, Banerjee A Acta Crystallogr D Struct Biol. 2018 Nov 1;74(Pt 11):1105-1114. doi:, 10.1107/S2059798318014146. Epub 2018 Oct 29. PMID:30387769<ref>PMID:30387769</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6cmv" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Banerjee, A]]
[[Category: Essen, L O]]
[[Category: Vogt, M S]]
[[Category: Archaea]]
[[Category: Biofilm]]
[[Category: Gene regulation]]
[[Category: Whth]]