View source for 6coi


==AtHNL enantioselectivity mutant At-A9-H7 Apo, Y13C,Y121L,P126F,L128W,C131T,A209I with CYANIDE, benzaldehyde, MANDELIC ACID NITRILE==
<StructureSection load='6coi' size='340' side='right'caption='[[6coi]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6coi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6COI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6COI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.024&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYN:CYANIDE+ION'>CYN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HBX:BENZALDEHYDE'>HBX</scene>, <scene name='pdbligand=MNN:(S)-MANDELIC+ACID+NITRILE'>MNN</scene>, <scene name='pdbligand=MXN:(2R)-HYDROXY(PHENYL)ETHANENITRILE'>MXN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6coi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6coi OCA], [https://pdbe.org/6coi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6coi RCSB], [https://www.ebi.ac.uk/pdbsum/6coi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6coi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HNL_ARATH HNL_ARATH] Involved in cyanogenesis, the release of HCN from injured tissues (By similarity). Displays R-selective hydroxynitrile lyase activity. Also accepts nitromethane (MeNO2) as a donor in a reaction with aromatic aldehydes to yield (R)-beta-nitro alcohols.<ref>PMID:18467465</ref> <ref>PMID:19433222</ref> <ref>PMID:21439333</ref> <ref>PMID:17907254</ref> 

==See Also==
*[[Methylesterase 3D structures|Methylesterase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Large Structures]]
[[Category: Desrouleaux R]]
[[Category: Jones BJ]]
[[Category: Kazlauskas RJ]]