View source for 6cpi


==Solution structure of SH3 domain from Shank1==
<StructureSection load='6cpi' size='340' side='right'caption='[[6cpi]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6cpi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CPI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CPI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cpi OCA], [https://pdbe.org/6cpi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cpi RCSB], [https://www.ebi.ac.uk/pdbsum/6cpi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cpi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SHAN1_HUMAN SHAN1_HUMAN] Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction.

==See Also==
*[[Shank protein|Shank protein]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Ishida H]]
[[Category: Vogel HJ]]