View source for 6cq7


==The SH3 domain of MLK3 in complex with poly-proline peptide derived from Htt==
<StructureSection load='6cq7' size='340' side='right'caption='[[6cq7]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6cq7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CQ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CQ7 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cq7 OCA], [https://pdbe.org/6cq7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cq7 RCSB], [https://www.ebi.ac.uk/pdbsum/6cq7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cq7 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/M3K11_HUMAN M3K11_HUMAN] Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.<ref>PMID:12529434</ref> <ref>PMID:15258589</ref> <ref>PMID:8195146</ref> <ref>PMID:9003778</ref> 

==See Also==
*[[Mitogen-activated protein kinase kinase kinase|Mitogen-activated protein kinase kinase kinase]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Kall SL]]
[[Category: Lavie A]]