View source for 6dau


==Crystal structure of E33Q and E41Q mutant forms of the spermidine/spermine N-acetyltransferase SpeG from Vibrio cholerae==
<StructureSection load='6dau' size='340' side='right'caption='[[6dau]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6dau]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_O1_biovar_El_Tor Vibrio cholerae O1 biovar El Tor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DAU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DAU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dau OCA], [https://pdbe.org/6dau PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dau RCSB], [https://www.ebi.ac.uk/pdbsum/6dau PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dau ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ATDA_VIBCH ATDA_VIBCH] Involved in the protection against polyamine toxicity by regulating their concentration. Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to the primary amino groups of spermidine to yield N(1)- and N(8)-acetylspermidine. It can use polyamines such as spermine and N(1)-acetylspermine, but not putrescine or cadaverine.<ref>PMID:23184347</ref> <ref>PMID:25623305</ref> 

==See Also==
*[[Spermidine/spermine N-acetyltransferase|Spermidine/spermine N-acetyltransferase]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Vibrio cholerae O1 biovar El Tor]]
[[Category: Anderson WF]]
[[Category: Beahan A]]
[[Category: Filippova EV]]
[[Category: Joachimiak A]]
[[Category: Kuhn ML]]
[[Category: Kulyavtsev P]]
[[Category: Minasov G]]
[[Category: Satchell KJF]]
[[Category: Tan L]]
[[Category: Tran D]]