View source for 6dew


==Structure of human COQ9 protein with bound isoprene.==
<StructureSection load='6dew' size='340' side='right'caption='[[6dew]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6dew]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DEW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DEW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=64Z:GERANIOL'>64Z</scene>, <scene name='pdbligand=FOF:(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol'>FOF</scene>, <scene name='pdbligand=FOH:FARNESOL'>FOH</scene>, <scene name='pdbligand=N1S:(2Z,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol'>N1S</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dew OCA], [https://pdbe.org/6dew PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dew RCSB], [https://www.ebi.ac.uk/pdbsum/6dew PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dew ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/COQ9_HUMAN COQ9_HUMAN] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The biosynthesis of coenzyme Q presents a paradigm for how cells surmount hydrophobic barriers in lipid biology. In eukaryotes, CoQ precursors-among nature's most hydrophobic molecules-must somehow be presented to a series of enzymes peripherally associated with the mitochondrial inner membrane. Here, we reveal that this process relies on custom lipid-binding properties of COQ9. We show that COQ9 repurposes the bacterial TetR fold to bind aromatic isoprenes with high specificity, including CoQ intermediates that likely reside entirely within the bilayer. We reveal a process by which COQ9 associates with cardiolipin-rich membranes and warps the membrane surface to access this cargo. Finally, we identify a molecular interface between COQ9 and the hydroxylase COQ7, motivating a model whereby COQ9 presents intermediates directly to CoQ enzymes. Overall, our results provide a mechanism for how a lipid-binding protein might access, select, and deliver specific cargo from a membrane to promote biosynthesis.

An Isoprene Lipid-Binding Protein Promotes Eukaryotic Coenzyme Q Biosynthesis.,Lohman DC, Aydin D, Von Bank HC, Smith RW, Linke V, Weisenhorn E, McDevitt MT, Hutchins P, Wilkerson EM, Wancewicz B, Russell J, Stefely MS, Beebe ET, Jochem A, Coon JJ, Bingman CA, Dal Peraro M, Pagliarini DJ Mol Cell. 2019 Jan 15. pii: S1097-2765(18)31003-7. doi:, 10.1016/j.molcel.2018.11.033. PMID:30661980<ref>PMID:30661980</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6dew" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bingman CA]]
[[Category: Lohman DC]]
[[Category: Pagliarini DJ]]
[[Category: Smith RW]]