View source for 6dlg


==Crystal structure of a SHIP1 surface entropy reduction mutant==
<StructureSection load='6dlg' size='340' side='right'caption='[[6dlg]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6dlg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DLG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DLG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.499&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dlg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dlg OCA], [https://pdbe.org/6dlg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dlg RCSB], [https://www.ebi.ac.uk/pdbsum/6dlg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dlg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SHIP1_MOUSE SHIP1_MOUSE] Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.<ref>PMID:11136821</ref> <ref>PMID:11222379</ref> <ref>PMID:11359765</ref> <ref>PMID:11896575</ref> <ref>PMID:12161749</ref> <ref>PMID:12370370</ref> <ref>PMID:12447389</ref> <ref>PMID:12882960</ref> <ref>PMID:14993273</ref> <ref>PMID:15166241</ref> <ref>PMID:17142780</ref> <ref>PMID:17173042</ref> <ref>PMID:8654924</ref> <ref>PMID:8805703</ref> <ref>PMID:9244303</ref> <ref>PMID:9620849</ref> <ref>PMID:9736736</ref> <ref>PMID:9763612</ref> <ref>PMID:9857188</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Cheung ST]]
[[Category: Gardill BR]]
[[Category: Mui AL]]
[[Category: Van Petegem F]]