View source for 6drc


==High IP3 Ca2+ human type 3 1,4,5-inositol trisphosphate receptor==
<SX load='6drc' size='340' side='right' viewer='molstar' caption='[[6drc]], [[Resolution|resolution]] 3.92&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6drc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DRC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DRC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.92&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6drc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6drc OCA], [https://pdbe.org/6drc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6drc RCSB], [https://www.ebi.ac.uk/pdbsum/6drc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6drc ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Inositol trisphosphate receptors (IP3Rs) are ubiquitous Ca(2+)-permeable channels that mediate release of Ca(2+) from the endoplasmic reticulum, thereby regulating numerous processes including cell division, cell death, differentiation and fertilization. IP3Rs are jointly activated by inositol trisphosphate (IP3) and their permeant ion, Ca(2+). At high concentrations, however, Ca(2+) inhibits activity, ensuring precise spatiotemporal control over intracellular Ca(2+). Despite extensive characterization of IP3R, the mechanisms through which these molecules control channel gating have remained elusive. Here, we present structures of full-length human type 3 IP3Rs in ligand-bound and ligand-free states. Multiple IP3-bound structures demonstrate that the large cytoplasmic domain provides a platform for propagation of long-range conformational changes to the ion-conduction gate. Structures in the presence of Ca(2+) reveal two Ca(2+)-binding sites that induce the disruption of numerous interactions between subunits, thereby inhibiting IP3R. These structures thus provide a mechanistic basis for beginning to understand the regulation of IP3R.

Structural basis for the regulation of inositol trisphosphate receptors by Ca(2+) and IP3.,Paknejad N, Hite RK Nat Struct Mol Biol. 2018 Jul 16. pii: 10.1038/s41594-018-0089-6. doi:, 10.1038/s41594-018-0089-6. PMID:30013099<ref>PMID:30013099</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 6drc" style="background-color:#fffaf0;"></div>

==See Also==
*[[Inositol 1%2C4%2C5-Trisphosphate Receptor|Inositol 1%2C4%2C5-Trisphosphate Receptor]]
== References ==
<references/>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Hite RK]]
[[Category: Paknejad N]]