View source for 6dtc


==Dihydrofolate Reductase (DHFR) of Aspergillus flavus in complex with a small molecule inhibitor==
<StructureSection load='6dtc' size='340' side='right'caption='[[6dtc]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6dtc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_flavus_NRRL3357 Aspergillus flavus NRRL3357]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DTC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DTC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=H9G:(3R)-3-methyl-4-[3-(1H-tetrazol-5-yl)phenoxy]-2,3-dihydrofuro[2,3-f]quinazoline-7,9-diamine'>H9G</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dtc OCA], [https://pdbe.org/6dtc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dtc RCSB], [https://www.ebi.ac.uk/pdbsum/6dtc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dtc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/B8NBN5_ASPFN B8NBN5_ASPFN] 

==See Also==
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
__TOC__
</StructureSection>
[[Category: Aspergillus flavus NRRL3357]]
[[Category: Large Structures]]
[[Category: Akers-Rodriguez S]]
[[Category: Bensen DC]]
[[Category: Fortier JM]]
[[Category: Tari LW]]