View source for 6ekl


==Crystal structure of mammalian Rev7 in complex with human Chromosome alignment-maintaining phosphoprotein 1==
<StructureSection load='6ekl' size='340' side='right'caption='[[6ekl]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6ekl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EKL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6EKL FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ekl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ekl OCA], [http://pdbe.org/6ekl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ekl RCSB], [http://www.ebi.ac.uk/pdbsum/6ekl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ekl ProSAT]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/CHAP1_HUMAN CHAP1_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry. 
== Function ==
[[http://www.uniprot.org/uniprot/MD2L2_MOUSE MD2L2_MOUSE]] Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation (By similarity). [[http://www.uniprot.org/uniprot/CHAP1_HUMAN CHAP1_HUMAN]] Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore.<ref>PMID:21063390</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Emamzadah, S]]
[[Category: Halazonetis, T]]
[[Category: Huber, F]]
[[Category: Tropia, L]]
[[Category: Champ1]]
[[Category: Chromosome alignment maintaining phosphoprotein 1]]
[[Category: Dna replication]]
[[Category: Mad2l2]]
[[Category: Replication]]
[[Category: Rev7]]