View source for 6ekm


==Crystal structure of mammalian Rev7 in complex with human Rev3 second binding site==
<StructureSection load='6ekm' size='340' side='right'caption='[[6ekm]], [[Resolution|resolution]] 2.76&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6ekm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EKM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6EKM FirstGlance]. <br>
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ekm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ekm OCA], [http://pdbe.org/6ekm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ekm RCSB], [http://www.ebi.ac.uk/pdbsum/6ekm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ekm ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/MD2L2_MOUSE MD2L2_MOUSE]] Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation (By similarity). [[http://www.uniprot.org/uniprot/REV3L_HUMAN REV3L_HUMAN]] Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function.<ref>PMID:24449906</ref>  

==See Also==
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: DNA-directed DNA polymerase]]
[[Category: Large Structures]]
[[Category: Emamzadah, S]]
[[Category: Halazonetis, T]]
[[Category: Huber, F]]
[[Category: Tropia, L]]
[[Category: Dna polymerase zeta]]
[[Category: Dna replication]]
[[Category: Mad2l2]]
[[Category: Replication]]
[[Category: Rev3]]
[[Category: Rev7]]