View source for 6ekt


==Structure of P47 from Clostridium botulinum A2==
<StructureSection load='6ekt' size='340' side='right'caption='[[6ekt]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6ekt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum_A2_str._Kyoto Clostridium botulinum A2 str. Kyoto]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EKT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EKT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ekt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ekt OCA], [https://pdbe.org/6ekt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ekt RCSB], [https://www.ebi.ac.uk/pdbsum/6ekt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ekt ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/C1FUH7_CLOBJ C1FUH7_CLOBJ] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Botulinum neurotoxins are highly toxic substances and are all encoded together with one of two alternative gene clusters, the HA or the OrfX gene cluster. Very little is known about the function and structure of the proteins encoded in the OrfX gene cluster, which in addition to the toxin contains five proteins (OrfX1, OrfX2, OrfX3, P47, and NTNH). We here present the structures of OrfX2 and P47, solved to 2.1 and 1.8 A, respectively. We show that they belong to the TULIP protein superfamily, which are often involved in lipid binding. OrfX1 and OrfX2 were both found to bind phosphatidylinositol lipids.

Crystal structures of OrfX2 and P47 from a Botulinum neurotoxin OrfX-type gene cluster.,Gustafsson R, Berntsson RP, Martinez-Carranza M, El Tekle G, Odegrip R, Johnson EA, Stenmark P FEBS Lett. 2017 Oct 25. doi: 10.1002/1873-3468.12889. PMID:29067689<ref>PMID:29067689</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6ekt" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Clostridium botulinum A2 str. Kyoto]]
[[Category: Large Structures]]
[[Category: Berntsson RP]]
[[Category: Stenmark P]]