View source for 6exz


==Crystal structure of Mex67 C-term==
<StructureSection load='6exz' size='340' side='right'caption='[[6exz]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6exz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EXZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EXZ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MEX67, YPL169C, P2520 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6exz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6exz OCA], [http://pdbe.org/6exz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6exz RCSB], [http://www.ebi.ac.uk/pdbsum/6exz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6exz ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/MEX67_YEAST MEX67_YEAST]] Involved in the export of mRNA from the nucleus to the cytoplasm.<ref>PMID:9214641</ref>  
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
RNA-binding proteins (RBPs) participate in all steps of gene expression, underscoring their potential as regulators of RNA homeostasis. We structurally and functionally characterize Mip6, a four-RNA recognition motif (RRM)-containing RBP, as a functional and physical interactor of the export factor Mex67. Mip6-RRM4 directly interacts with the ubiquitin-associated (UBA) domain of Mex67 through a loop containing tryptophan 442. Mip6 shuttles between the nucleus and the cytoplasm in a Mex67-dependent manner and concentrates in cytoplasmic foci under stress. Photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation experiments show preferential binding of Mip6 to mRNAs regulated by the stress-response Msn2/4 transcription factors. Consistent with this binding, MIP6 deletion affects their export and expression levels. Additionally, Mip6 interacts physically and/or functionally with proteins with a role in mRNA metabolism and transcription such as Rrp6, Xrn1, Sgf73, and Rpb1. These results reveal a novel role for Mip6 in the homeostasis of Msn2/4-dependent transcripts through its direct interaction with the Mex67 UBA domain.

Mip6 binds directly to the Mex67 UBA domain to maintain low levels of Msn2/4 stress-dependent mRNAs.,Martin-Exposito M, Gas ME, Mohamad N, Nuno-Cabanes C, Tejada-Colon A, Pascual-Garcia P, de la Fuente L, Chaves-Arquero B, Merran J, Corden J, Conesa A, Perez-Canadillas JM, Bravo J, Rodriguez-Navarro S EMBO Rep. 2019 Nov 3:e47964. doi: 10.15252/embr.201947964. PMID:31680439<ref>PMID:31680439</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6exz" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Baker's yeast]]
[[Category: Large Structures]]
[[Category: Bravo, J]]
[[Category: Mohamad, N]]
[[Category: Mrna export]]
[[Category: Transport protein]]