View source for 6ey0


==N-terminal part (residues 30-212) of PorM with the llama nanobody nb01==
<StructureSection load='6ey0' size='340' side='right' caption='[[6ey0]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6ey0]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_33277 Atcc 33277] and [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EY0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EY0 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">porM, PGIN_15-9_01458 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=837 ATCC 33277])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ey0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ey0 OCA], [http://pdbe.org/6ey0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ey0 RCSB], [http://www.ebi.ac.uk/pdbsum/6ey0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ey0 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Type IX secretion system (T9SS), exclusively present in the Bacteroidetes phylum, has been studied mainly in Flavobacterium johnsoniae and Porphyromonas gingivalis. Among the 18 genes, essential for T9SS function, a group of four, porK-N (P. gingivalis) or gldK-N (F. johnsoniae) belongs to a co-transcribed operon that expresses the T9SS core membrane complex. The central component of this complex, PorM (or GldM), is anchored in the inner membrane by a trans-membrane helix and interacts through the outer membrane PorK-N complex. There is a complete lack of available atomic structures for any component of T9SS, including the PorKLMN complex. Here we report the crystal structure of the GldM and PorM periplasmic domains. Dimeric GldM and PorM, each contain four domains of ~180-A length that span most of the periplasmic space. These and previously reported results allow us to propose a model of the T9SS core membrane complex as well as its functional behavior.

Type IX secretion system PorM and gliding machinery GldM form arches spanning the periplasmic space.,Leone P, Roche J, Vincent MS, Tran QH, Desmyter A, Cascales E, Kellenberger C, Cambillau C, Roussel A Nat Commun. 2018 Jan 30;9(1):429. doi: 10.1038/s41467-017-02784-7. PMID:29382829<ref>PMID:29382829</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6ey0" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Atcc 33277]]
[[Category: Camelus glama]]
[[Category: Cambillau, C]]
[[Category: Leone, P]]
[[Category: Roche, J]]
[[Category: Roussel, A]]
[[Category: Nanobody]]
[[Category: Protein transport]]