View source for 6f68


==Crystal structure glutathione transferase Omega 3S from Trametes versicolor in complex with 2,4,4'-trihydroxybenzophenone==
<StructureSection load='6f68' size='340' side='right' caption='[[6f68]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6f68]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bjerkandera_versicolor Bjerkandera versicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F68 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6F68 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4EU:(2,4-DIHYDROXYPHENYL)(4-HYDROXYPHENYL)METHANONE'>4EU</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6f43|6f43]], [[6f4b|6f4b]], [[6f4f|6f4f]], [[6f4k|6f4k]], [[6f51|6f51]], [[6f66|6f66]], [[6f67|6f67]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6f68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f68 OCA], [http://pdbe.org/6f68 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6f68 RCSB], [http://www.ebi.ac.uk/pdbsum/6f68 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6f68 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Wood decay fungi have complex detoxification systems that enable them to cope with secondary metabolites produced by plants. Although the number of genes encoding for glutathione transferases is especially expanded in lignolytic fungi, little is known about their target molecules. In this study, by combining biochemical, enzymatic and structural approaches, interactions between polyphenols and six glutathione transferases from the white-rot fungus Trametes versicolor have been demonstrated. Two isoforms, named TvGSTO3S and TvGSTO6S have been deeply studied at the structural level. Each isoform shows two distinct ligand-binding sites, a narrow L-site at the dimer interface and a peculiar deep hydrophobic H-site. In TvGSTO3S, the latter appears optimized for aromatic ligand binding such as hydroxybenzophenones. Affinity crystallography revealed that this H-site retains the flavonoid dihydrowogonin from a partially purified wild-cherry extract. Besides, TvGSTO6S binds two molecules of the flavonoid naringenin in the L-site. These data suggest that TvGSTO isoforms could interact with plant polyphenols released during wood degradation.

Molecular recognition of wood polyphenols by phase II detoxification enzymes of the white rot Trametes versicolor.,Schwartz M, Perrot T, Aubert E, Dumarcay S, Favier F, Gerardin P, Morel-Rouhier M, Mulliert G, Saiag F, Didierjean C, Gelhaye E Sci Rep. 2018 May 31;8(1):8472. doi: 10.1038/s41598-018-26601-3. PMID:29855494<ref>PMID:29855494</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6f68" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bjerkandera versicolor]]
[[Category: Didierjean, C]]
[[Category: Favier, F]]
[[Category: Schwartz, M]]
[[Category: Fungi]]
[[Category: Glutathione]]
[[Category: Polyphenol]]
[[Category: Transferase]]
[[Category: Wood decayer]]