View source for 6fa9


==CRYSTAL STRUCTURE OF THE DEAH-BOX HELICASE PRP2==
<StructureSection load='6fa9' size='340' side='right' caption='[[6fa9]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6fa9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FA9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FA9 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fa9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fa9 OCA], [http://pdbe.org/6fa9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fa9 RCSB], [http://www.ebi.ac.uk/pdbsum/6fa9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fa9 ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
The DEAH-box ATPase Prp2 plays a key role in the activation of the spliceosome as it promotes the transition from the B(act) to the catalytically active B* spliceosome. Here, four crystal structures of Prp2 are reported: one of the nucleotide-free state and three different structures of the ADP-bound state. The overall conformation of the helicase core, formed by two RecA-like domains, does not differ significantly between the ADP-bound and the nucleotide-free states. However, intrinsic flexibility of Prp2 is observed, varying the position of the C-terminal domains with respect to the RecA domains. Additionally, in one of the structures a unique ADP conformation is found which has not been observed in any other DEAH-box, DEAD-box or NS3/NPH-II helicase.

Crystal structure of the spliceosomal DEAH-box ATPase Prp2.,Schmitt A, Hamann F, Neumann P, Ficner R Acta Crystallogr D Struct Biol. 2018 Jul 1;74(Pt 7):643-654. doi:, 10.1107/S2059798318006356. Epub 2018 Jun 8. PMID:29968674<ref>PMID:29968674</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 6fa9" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Ficner, R]]
[[Category: Hamann, F]]
[[Category: Neumann, P]]
[[Category: Schmitt, A]]
[[Category: Atpase]]
[[Category: G-patch]]
[[Category: Helicase]]
[[Category: Hydrolase]]
[[Category: Splicing]]