View source for 6fdz


==Unc-51-Like Kinase 3 (ULK3) In Complex With Momelotinib==
<StructureSection load='6fdz' size='340' side='right' caption='[[6fdz]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6fdz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FDZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FDZ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C87:Momelotinib'>C87</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fdz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fdz OCA], [http://pdbe.org/6fdz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fdz RCSB], [http://www.ebi.ac.uk/pdbsum/6fdz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fdz ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/ULK3_HUMAN ULK3_HUMAN]] Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.<ref>PMID:19279323</ref> <ref>PMID:19878745</ref> <ref>PMID:20643644</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Delft, F von]]
[[Category: Edwards, A M]]
[[Category: Huber, K]]
[[Category: Knapp, S]]
[[Category: Mathea, S]]
[[Category: Moroglu, M]]
[[Category: Pike, A C.W]]
[[Category: Salah, E]]
[[Category: Scorah, A]]
[[Category: Kinase inhibitor dfg-out]]
[[Category: Transferase]]