View source for 6fjl


==Structure of IbpS from Dickeya dadantii==
<StructureSection load='6fjl' size='340' side='right'caption='[[6fjl]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6fjl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Dickeya_dadantii_3937 Dickeya dadantii 3937]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FJL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FJL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7000004&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fjl OCA], [https://pdbe.org/6fjl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fjl RCSB], [https://www.ebi.ac.uk/pdbsum/6fjl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fjl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/E0SCP7_DICD3 E0SCP7_DICD3] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Few secreted proteins involved in plant infection common to necrotrophic bacteria, fungi and oomycetes have been identified except for plant cell wall-degrading enzymes. Here we study a family of iron-binding proteins that is present in Gram-negative and Gram-positive bacteria, fungi, oomycetes and some animals. Homolog proteins in the phytopathogenic bacterium Dickeya dadantii (IbpS) and the fungal necrotroph Botrytis cinerea (BcIbp) are involved in plant infection. IbpS is secreted, can bind iron and copper, and protects the bacteria against H2O2-induced death. Its 1.7 A crystal structure reveals a classical Venus Fly trap fold that forms dimers in solution and in the crystal. We propose that secreted Ibp proteins binds exogenous metals and thus limit intracellular metal accumulation and ROS formation in the microorganisms.

A secreted metal-binding protein protects necrotrophic phytopathogens from reactive oxygen species.,Liu L, Gueguen-Chaignon V, Goncalves IR, Rascle C, Rigault M, Dellagi A, Loisel E, Poussereau N, Rodrigue A, Terradot L, Condemine G Nat Commun. 2019 Oct 24;10(1):4853. doi: 10.1038/s41467-019-12826-x. PMID:31649262<ref>PMID:31649262</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6fjl" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Dickeya dadantii 3937]]
[[Category: Large Structures]]
[[Category: Condemine G]]
[[Category: Gueguen-Chaignon V]]
[[Category: Terradot L]]