View source for 6g22


==Crystal structure of human mitochondrial 5'(3')-deoxyribonucleotidase in complex with the inhibitor PB-PEU==
<StructureSection load='6g22' size='340' side='right' caption='[[6g22]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6g22]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G22 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G22 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2O2:1-{2-DEOXY-3,5-O-[PHENYL(PHOSPHONO)METHYLIDENE]-BETA-D-THREO-PENTOFURANOSYL}-5-[(E)-2-PHOSPHONOETHENYL]PYRIMIDINE-2,4(1H,3H)-DIONE'>2O2</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6g2l|6g2l]], [[6g2m|6g2m]], [[6g2n|6g2n]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g22 OCA], [http://pdbe.org/6g22 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g22 RCSB], [http://www.ebi.ac.uk/pdbsum/6g22 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g22 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/NT5M_HUMAN NT5M_HUMAN]] Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP. 
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</StructureSection>
[[Category: Brynda, J]]
[[Category: Pachl, P]]
[[Category: Rezacova, P]]
[[Category: 5'-nucleotidase]]
[[Category: Dephosphorylation]]
[[Category: Had-like]]
[[Category: Hydrolase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Mitochondria]]
[[Category: Phosphorylation]]