View source for 6ggz


==NMR structure of the scorpion toxin AmmTx3==
<StructureSection load='6ggz' size='340' side='right'caption='[[6ggz]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6ggz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Androctonus_mauritanicus_mauritanicus Androctonus mauritanicus mauritanicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GGZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6GGZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ggz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ggz OCA], [https://pdbe.org/6ggz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ggz RCSB], [https://www.ebi.ac.uk/pdbsum/6ggz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ggz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KA153_ANDMA KA153_ANDMA] Blocker of A-type voltage-gated potassium channels of striated neurons (PubMed:12473099). Has been shown to block ERG1/Kv11.1/KCNH2 potassium channels (IC(50)=7.9 uM) (PubMed:18687312). In adult rat brain, it binds to sites in the striatum, and cerebellum. It shares the same target in rat brain than AaTX1 (AC Q867F4) and BmTX3 (AC Q8I0L5).<ref>PMID:12473099</ref> <ref>PMID:18687312</ref> 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The scorpion toxin AmmTx3 is a specific blocker of Kv4 channels. It was shown to have interesting potential for neurological disorders. In this study, we report the first chemical synthesis of AmmTx3 by using the native chemical ligation strategy and validate its biological activity. We determined its 3D structure by nuclear magnetic resonance spectroscopy, and pointed out that AmmTx3 possesses the well-known CSalphabeta structural motif, which is found in a large number of scorpion toxins. Overall, this study establishes an easy synthetic access to biologically active AmmTx3 toxin.

Synthesis by native chemical ligation and characterization of the scorpion toxin AmmTx3.,Zoukimian C, Meudal H, De Waard S, Ouares KA, Nicolas S, Canepari M, Beroud R, Landon C, De Waard M, Boturyn D Bioorg Med Chem. 2019 Jan 1;27(1):247-253. doi: 10.1016/j.bmc.2018.12.009. Epub, 2018 Dec 6. PMID:30529150<ref>PMID:30529150</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6ggz" style="background-color:#fffaf0;"></div>

==See Also==
*[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Androctonus mauritanicus mauritanicus]]
[[Category: Large Structures]]
[[Category: Landon C]]
[[Category: Meudal H]]