View source for 6gii


==The crystal structure of Tepidiphilus thermophilus P450 heme domain==
<StructureSection load='6gii' size='340' side='right' caption='[[6gii]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6gii]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dsm_2722 Dsm 2722]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GII OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GII FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ga0061068_103196 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=876478 DSM 2722])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gii OCA], [http://pdbe.org/6gii PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gii RCSB], [http://www.ebi.ac.uk/pdbsum/6gii PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gii ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
The first crystal structure of a class VII P450, CYP116B46 from Tepidiphilus thermophilus, has been solved at 1.9A resolution. The structure reveals overall conservation of the P450-fold and a water conduit around the I-helix. Active site residues have been identified and sequence comparisons have been made with other class VII enzymes. A structure similarity search demonstrated that the P450-TT structure is similar to enzymes capable of oxy-functionalization of fatty acids, terpenes, macrolides, steroids and statins. The insight gained from solving this structure will provide a guideline for future engineering and modelling studies on this catalytically promiscuous class of enzymes.

The crystal structure of P450-TT heme-domain provides the first structural insights into the versatile class VII P450s.,Tavanti M, Porter JL, Levy CW, Gomez Castellanos JR, Flitsch SL, Turner NJ Biochem Biophys Res Commun. 2018 May 17. pii: S0006-291X(18)31059-3. doi:, 10.1016/j.bbrc.2018.05.014. PMID:29738765<ref>PMID:29738765</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 6gii" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Dsm 2722]]
[[Category: Levy, C W]]
[[Category: Cytochrome p450 class vii]]
[[Category: Oxidoreductase]]