View source for 6gll


==Crystal structure of hMTH1 N33A in complex with LW14 in the presence of acetate==
<StructureSection load='6gll' size='340' side='right' caption='[[6gll]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6gll]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GLL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GLL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BU8:1~{H}-imidazo[4,5-b]pyridin-2-amine'>BU8</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gll OCA], [http://pdbe.org/6gll PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gll RCSB], [http://www.ebi.ac.uk/pdbsum/6gll PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gll ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Caflisch, A]]
[[Category: Eberle, S A]]
[[Category: Sledz, P]]
[[Category: Wiedmer, L]]
[[Category: Complex]]
[[Category: Dna repair]]
[[Category: Fragment]]
[[Category: Hydrolase]]
[[Category: Inhibitor]]