View source for 6gmb


==Structure of human hydroxyacid oxidase 1 bound with FMN and glycolate==
<StructureSection load='6gmb' size='340' side='right'caption='[[6gmb]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6gmb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GMB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6GMB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOA:GLYCOLIC+ACID'>GOA</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6gmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gmb OCA], [https://pdbe.org/6gmb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6gmb RCSB], [https://www.ebi.ac.uk/pdbsum/6gmb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6gmb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HAOX1_HUMAN HAOX1_HUMAN] Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate.

==See Also==
*[[Glycolate oxidase 3D structures|Glycolate oxidase 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bezerra GA]]
[[Category: Bountra C]]
[[Category: Brennan PE]]
[[Category: Edwards E]]
[[Category: Krojer T]]
[[Category: MacKinnon S]]
[[Category: Oppermann U]]
[[Category: Smee C]]
[[Category: Yue WW]]