View source for 6gw3


==Structure of TKS from Cannabis sativa in complex with CoA==
<StructureSection load='6gw3' size='340' side='right'caption='[[6gw3]], [[Resolution|resolution]] 1.39&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6gw3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Cannabis_sativa Cannabis sativa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6GW3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.39&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6gw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gw3 OCA], [https://pdbe.org/6gw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6gw3 RCSB], [https://www.ebi.ac.uk/pdbsum/6gw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6gw3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/OLIS_CANSA OLIS_CANSA] Polyketide synthase responsible for olivetol biosynthesis. Catalyzes the first step in the cannabinoids biosynthetic pathway. The preferred substrate is hexanoyl-CoA, but accepts also CoA esters with C4 to C8 aliphatic side chains. When using malonyl-CoA and hexanoyl-CoA as substrates, produces undetermined compounds distinct form olivetol or olivetolic acid (PubMed:19581347) that could be hexanoyl triacetic acid lactone (HTAL) (PubMed:18323613) and pentyl diacetic acid lactone (PDAL) (PubMed:22802619). Produces olivetolic acid when acting in concert with olivetolic acid cyclase (OAC).<ref>PMID:18323613</ref> <ref>PMID:19454282</ref> <ref>PMID:19581347</ref> <ref>PMID:22802619</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Cannabis sativa]]
[[Category: Large Structures]]
[[Category: Karuppiah V]]
[[Category: Leys D]]