View source for 6gzn


==Adenine-driven structural switch from two- to three-quartet DNA G-quadruplex==
<StructureSection load='6gzn' size='340' side='right'caption='[[6gzn]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6gzn]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GZN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GZN FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gzn OCA], [http://pdbe.org/6gzn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gzn RCSB], [http://www.ebi.ac.uk/pdbsum/6gzn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gzn ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
G-rich sequence found in the regulatory region of RANKL gene associated with homeostasis of bone metabolism folds into a two-quartet basket-type G-quadruplex stabilized by A*G*A and G*G*G base-triads. Perusal of local structural features together with G/A-to-T modifications uncovered critical role of A5 for formation of distinct antiparallel two-quartet and not three-quartet topology that would be expected based on sequence with four GGG-tracts alone. Structural changes induced by A5-to-T5 modification include a switch in orientation and relative positions of G-strands that together with anti to syn reorientation of G12 provide insights into complexity of intricate interactions that influence folding process of G-rich DNA. Understanding the impact of loop residues for overall stability and formation of G-quadruplexes advances our knowledge and ability to predict structures adopted by G-rich sequences which are involved in regulatory mechanisms in cell and may also facilitate drug design driven by structural insights.

Adenine-driven structural switch from two- to three-quartet DNA G-quadruplex.,Plavec J, Lenarcic Zivkovic M, Rozman J Angew Chem Int Ed Engl. 2018 Sep 17. doi: 10.1002/anie.201809328. PMID:30222243<ref>PMID:30222243</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6gzn" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Plavec, J]]
[[Category: Rozman, J]]
[[Category: Zivkovic, M Lenarcic]]
[[Category: Basket-type topology]]
[[Category: Dna]]
[[Category: G-quadruplex]]
[[Category: Osteoporosis]]
[[Category: Rankl gene]]