View source for 6hpi


==NMR structure of the pro-inflammatory cytokine interleukin-36alpha==
<StructureSection load='6hpi' size='340' side='right'caption='[[6hpi]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6hpi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HPI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HPI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hpi OCA], [https://pdbe.org/6hpi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hpi RCSB], [https://www.ebi.ac.uk/pdbsum/6hpi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hpi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IL36A_HUMAN IL36A_HUMAN] Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by upregulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T-cell proliferation. May play a role in proinflammatory effects in the lung.<ref>PMID:14734551</ref> <ref>PMID:21881584</ref> <ref>PMID:21965679</ref> <ref>PMID:24829417</ref> 

==See Also==
*[[Interleukin 3D structures|Interleukin 3D structures]]
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Imhof D]]
[[Category: Ohlenschlaeger O]]