View source for 6iat


==Icosahedrally averaged capsid of bacteriophage P68==
<SX load='6iat' size='340' side='right' viewer='molstar' caption='[[6iat]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6iat]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_phage_p68 Staphylococcus phage p68]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IAT OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6IAT FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6iat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iat OCA], [http://pdbe.org/6iat PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6iat RCSB], [http://www.ebi.ac.uk/pdbsum/6iat PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6iat ProSAT]</span></td></tr>
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== Publication Abstract from PubMed ==
Phages infecting Staphylococcus aureus can be used as therapeutics against antibiotic-resistant bacterial infections. However, there is limited information about the mechanism of genome delivery of phages that infect Gram-positive bacteria. Here, we present the structures of native S. aureus phage P68, genome ejection intermediate, and empty particle. The P68 head contains 72 subunits of inner core protein, 15 of which bind to and alter the structure of adjacent major capsid proteins and thus specify attachment sites for head fibers. Unlike in the previously studied phages, the head fibers of P68 enable its virion to position itself at the cell surface for genome delivery. The unique interaction of one end of P68 DNA with one of the 12 portal protein subunits is disrupted before the genome ejection. The inner core proteins are released together with the DNA and enable the translocation of phage genome across the bacterial membrane into the cytoplasm.

Structure and genome ejection mechanism of Staphylococcus aureus phage P68.,Hrebik D, Stverakova D, Skubnik K, Fuzik T, Pantucek R, Plevka P Sci Adv. 2019 Oct 16;5(10):eaaw7414. doi: 10.1126/sciadv.aaw7414. eCollection, 2019 Oct. PMID:31663016<ref>PMID:31663016</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
<references/>
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[[Category: Large Structures]]
[[Category: Staphylococcus phage p68]]
[[Category: Fuzik, T]]
[[Category: Hrebik, D]]
[[Category: Plevka, P]]
[[Category: Skubnik, K]]
[[Category: Bacteriophage capsid]]
[[Category: Hk97 fold]]
[[Category: Structural protein]]