View source for 6ie1


==Crystal Structure of ELMO2(Engulfment and cell motility protein 2)==
<StructureSection load='6ie1' size='340' side='right'caption='[[6ie1]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6ie1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IE1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IE1 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.48&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ie1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ie1 OCA], [https://pdbe.org/6ie1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ie1 RCSB], [https://www.ebi.ac.uk/pdbsum/6ie1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ie1 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/ELMO2_HUMAN ELMO2_HUMAN] Ramon syndrome;Primary intraosseous venous malformation. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/ELMO2_HUMAN ELMO2_HUMAN] Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.<ref>PMID:11595183</ref> <ref>PMID:11703939</ref> <ref>PMID:20679435</ref> <ref>PMID:27476657</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Lin L]]
[[Category: Weng ZF]]
[[Category: Zhang RG]]
[[Category: Zhu JW]]