View source for 6ie7


==Crystal structure of ADCP1 tandem Agenet domain 1-2 in complex with H3K9me2==
<StructureSection load='6ie7' size='340' side='right'caption='[[6ie7]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6ie7]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IE7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IE7 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ie7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ie7 OCA], [https://pdbe.org/6ie7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ie7 RCSB], [https://www.ebi.ac.uk/pdbsum/6ie7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ie7 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AGDP1_ARATH AGDP1_ARATH] Heterochromatin-binding protein that preferentially occupies long transposons and specifically recognizes the histone H3 'Lys-9' methylation (H3K9me) marks, with a stronger affinity for dimethylated H3K9 (H3K9me2) (PubMed:30382101, PubMed:30425322). Required for transcriptional silencing, non-CG DNA methylation (e.g. CHG and CHH regions), and H3K9 dimethylation (H3K9me2) at some loci (PubMed:30382101, PubMed:30425322). Mediates heterochromatin phase separation and chromocenter formation (PubMed:30425322).<ref>PMID:30382101</ref> <ref>PMID:30425322</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Large Structures]]
[[Category: Li H]]
[[Category: Zhang B]]
[[Category: Zhao S]]