View source for 6iio


==Cryo-EM structure of CV-A10 native empty particle==
<SX load='6iio' size='340' side='right' viewer='molstar' caption='[[6iio]], [[Resolution|resolution]] 3.12&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6iio]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Coxsackievirus_A10 Coxsackievirus A10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IIO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IIO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.12&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6iio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iio OCA], [https://pdbe.org/6iio PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6iio RCSB], [https://www.ebi.ac.uk/pdbsum/6iio PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6iio ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A1B3Z4Y8_9ENTO A0A1B3Z4Y8_9ENTO] 
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== Publication Abstract from PubMed ==
Coxsackievirus A10 (CV-A10) belongs to the Enterovirus species A and is a causative agent of hand, foot, and mouth disease. Here we present cryo-EM structures of CV-A10 mature virion and native empty particle (NEP) at 2.84 and 3.12 A, respectively. Our CV-A10 mature virion structure reveals a density corresponding to a lipidic pocket factor of 18 carbon atoms in the hydrophobic pocket formed within viral protein 1. By structure-guided high-throughput drug screening and subsequent verification in cell-based infection-inhibition assays, we identified four compounds that inhibited CV-A10 infection in vitro. These compounds represent a new class of anti-enteroviral drug leads. Notably, one of the compounds, ICA135, also exerted broad-spectrum inhibitory effects on a number of representative viruses from all four species (A-D) of human enteroviruses. Our findings should facilitate the development of broadly effective drugs and vaccines for enterovirus infections.

Coxsackievirus A10 atomic structure facilitating the discovery of a broad-spectrum inhibitor against human enteroviruses.,Chen J, Ye X, Zhang XY, Zhu Z, Zhang X, Xu Z, Ding Z, Zou G, Liu Q, Kong L, Jiang W, Zhu W, Cong Y, Huang Z Cell Discov. 2019 Jan 15;5:4. doi: 10.1038/s41421-018-0073-7. eCollection 2019. PMID:30652025<ref>PMID:30652025</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 6iio" style="background-color:#fffaf0;"></div>

==See Also==
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
== References ==
<references/>
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[[Category: Coxsackievirus A10]]
[[Category: Large Structures]]
[[Category: Chen JH]]
[[Category: Cong Y]]
[[Category: Huang Z]]
[[Category: Ye XH]]