View source for 6ik4


==A Novel M23 Metalloprotease Pseudoalterin from Deep-sea==
<StructureSection load='6ik4' size='340' side='right'caption='[[6ik4]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6ik4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudoalteromonas_sp._CF6-2 Pseudoalteromonas sp. CF6-2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IK4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IK4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ik4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ik4 OCA], [https://pdbe.org/6ik4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ik4 RCSB], [https://www.ebi.ac.uk/pdbsum/6ik4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ik4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/E7D102_9GAMM E7D102_9GAMM] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Predator-prey interactions play important roles in the cycling of marine organic matter. Here we show that a Gram-negative bacterium isolated from marine sediments (Pseudoalteromonas sp. strain CF6-2) can kill Gram-positive bacteria of diverse peptidoglycan (PG) chemotypes by secreting the metalloprotease pseudoalterin. Secretion of the enzyme requires a Type II secretion system. Pseudoalterin binds to the glycan strands of Gram positive bacterial PG and degrades the PG peptide chains, leading to cell death. The released nutrients, including PG-derived D-amino acids, can then be utilized by strain CF6-2 for growth. Pseudoalterin synthesis is induced by PG degradation products such as glycine and glycine-rich oligopeptides. Genes encoding putative pseudoalterin-like proteins are found in many other marine bacteria. This study reveals a new microbial interaction in the ocean.

A predator-prey interaction between a marine Pseudoalteromonas sp. and Gram-positive bacteria.,Tang BL, Yang J, Chen XL, Wang P, Zhao HL, Su HN, Li CY, Yu Y, Zhong S, Wang L, Lidbury I, Ding H, Wang M, McMinn A, Zhang XY, Chen Y, Zhang YZ Nat Commun. 2020 Jan 15;11(1):285. doi: 10.1038/s41467-019-14133-x. PMID:31941905<ref>PMID:31941905</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6ik4" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudoalteromonas sp. CF6-2]]
[[Category: Chen XL]]
[[Category: Tang BL]]
[[Category: Yang J]]
[[Category: Zhang YZ]]
[[Category: Zhao HL]]