View source for 6imh


==Solution Structure of Bicyclic Peptide pb-18==
<StructureSection load='6imh' size='340' side='right'caption='[[6imh]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6imh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_M13 Escherichia virus M13]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IMH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IMH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6imh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6imh OCA], [https://pdbe.org/6imh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6imh RCSB], [https://www.ebi.ac.uk/pdbsum/6imh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6imh ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Bicyclic peptides are attractive scaffolds for the design of potent protein binders and new therapeutics. However, peptide bicycles constrained through disulfide bonds are rarely stable or tolerant to sequence manipulation owing to disulfide isomerization, especially for peptides lacking a regular secondary structure. Herein, we report the discovery and identification of a class of bicyclic peptide scaffolds with ordered but irregular secondary structures. These peptides have a conserved cysteine/proline framework for directing the oxidative folding into a fused bicyclic structure that consists of four irregular turns and a 310 helix (characterized by NMR spectroscopy). This work shows that bicyclic peptides can be stabilized into ordered structures by manipulating both the disulfide bonds and proline-stabilized turns. In turn, this could inspire the design and engineering of multicyclic peptides with new structures and benefit the development of novel protein binders and therapeutics.

Ordered and Isomerically Stable Bicyclic Peptide Scaffolds Constrained through Cystine Bridges and Proline Turns.,Lin P, Yao H, Zha J, Zhao Y, Wu C Chembiochem. 2019 Jun 14;20(12):1514-1518. doi: 10.1002/cbic.201800788. Epub 2019, Apr 18. PMID:30770638<ref>PMID:30770638</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6imh" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Escherichia virus M13]]
[[Category: Large Structures]]
[[Category: Lin P]]
[[Category: Wu C]]
[[Category: Yao H]]
[[Category: Zha J]]
[[Category: Zha M]]
[[Category: Zhao Y]]