View source for 6in3


==Crystal structure of DOT1L in complex with 18-Crown-6==
<StructureSection load='6in3' size='340' side='right'caption='[[6in3]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6in3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IN3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IN3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=O4B:1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE'>O4B</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6in3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6in3 OCA], [https://pdbe.org/6in3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6in3 RCSB], [https://www.ebi.ac.uk/pdbsum/6in3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6in3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.

==See Also==
*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Kitakami R]]
[[Category: Kosaka Y]]
[[Category: Matsumoto K]]
[[Category: Mizuguchi M]]
[[Category: Nabeshima Y]]
[[Category: Yokoyama T]]