View source for 6ioz


==Structural insights of idursulfase beta==
<StructureSection load='6ioz' size='340' side='right'caption='[[6ioz]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6ioz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IOZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IOZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALS:(3S)-3-(SULFOOXY)-L-SERINE'>ALS</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ioz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ioz OCA], [https://pdbe.org/6ioz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ioz RCSB], [https://www.ebi.ac.uk/pdbsum/6ioz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ioz ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/IDS_HUMAN IDS_HUMAN] Mucopolysaccharidosis type 2, attenuated form;Mucopolysaccharidosis type 2, severe form. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/IDS_HUMAN IDS_HUMAN] Required for the lysosomal degradation of heparan sulfate and dermatan sulfate.

==See Also==
*[[Sulfatase 3D structures|Sulfatase 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Hong J]]
[[Category: Kim D]]
[[Category: Kim H]]
[[Category: Lee K]]
[[Category: Oh BH]]
[[Category: Seo J]]